What Semax is
Semax is a synthetic heptapeptide, Met-Glu-His-Phe-Pro-Gly-Pro. Its first four residues match positions 4 to 7 of adrenocorticotropic hormone (ACTH), a fragment that is processed from the POMC precursor protein, and the C-terminal Pro-Gly-Pro tripeptide was appended to slow enzymatic breakdown of the fragment. The result is a short, linear peptide with one acidic residue (glutamate), one histidine and a single methionine.
Semax Labs supplies Semax as a lyophilized powder in 10 mg vials. Every lot is tested by an independent laboratory for HPLC-UV purity, LC-MS identity and net content, and the certificate is published here, lot by lot, before the material is sold through Klow.bio.
Structure
Semax is linear with a free N-terminus (Met1) and free C-terminal acid (Pro7). Methionine 1 is the residue most sensitive to oxidation, which adds 16 Da per oxygen and is one of the changes LC-MS can detect. The molecule contains no cysteine or tryptophan.
complete Semax specifications.
Storage and handling
Store sealed, dry and protected from light at the temperature stated on the vial label. Allow a cold vial to reach room temperature before opening. Lyophilized material absorbs moisture from the air, and absorbed moisture restarts the reactions that drying slows, so keep vials sealed until needed. Storage and stability guide.