Semax research: overview and resources
Everything Semax Labs publishes on Semax research material: the ACTH-derived sequence, the analytical methods applied to each lot, and links to specifications, lot records and references.
What is Semax?
Semax is a synthetic heptapeptide, Met-Glu-His-Phe-Pro-Gly-Pro. Its first four residues match positions 4 to 7 of adrenocorticotropic hormone (ACTH), a fragment that is processed from the POMC precursor protein, and the C-terminal Pro-Gly-Pro tripeptide was appended to slow enzymatic breakdown of the fragment. The result is a short, linear peptide with one acidic residue (glutamate), one histidine and a single methionine.
Semax Labs supplies Semax as a lyophilized powder in 10 mg vials. Every lot is tested by an independent laboratory for HPLC-UV purity, LC-MS identity and net content, and the certificate is published here, lot by lot, before the material is sold through Klow.bio.
What is Semax research material?
Semax research material is Semax supplied for laboratory research (C37H51N9O10S, 813.93 g/mol) in white lyophilized powder form, sold by lot. Each lot's identity, purity and net content are documented by an independent laboratory in a published certificate of analysis.
How is Semax characterized?
Three questions are answered for every lot, each by a different method:
- Is it the right compound? LC-MS separates the sample and measures the mass of the main component, confirming it has the molecular weight expected for the compound.
- How much of the sample is that compound? HPLC-UV reports the main peak's share of detected peak area. Current lots: 99.84%.
- How much peptide is in the vial? Net content is measured directly.
Endotoxin (LAL) and microbial DNA (PCR) results are added where those tests are run.
What has not been established
A certificate of analysis describes the specific sample tested on its test date. It does not establish stability afterward, sequence order beyond what mass confirmation shows, results for other lots, or suitability for any particular purpose.
Semax at a glance
- Product
- Semax
- Type
- Synthetic heptapeptide, 7 residues
- Also known as
- ACTH(4-7)-Pro-Gly-Pro, Met-Glu-His-Phe-Pro-Gly-Pro
- Molecular formula
- C37H51N9O10S
- Molecular weight
- 813.93 g/mol (average)
- Form
- White lyophilized powder
- Vial sizes
- 10 mg
- Purity, current lots
- 99.84% (HPLC-UV)
- Purity specification
- ≥95%
- Identity
- Confirmed by LC-MS on every lot
- Testing laboratory
- Freedom Diagnostics (independent)
- Current lot
- KB29412, reported Jun 7, 2026
- Operated by
- Klow Labs LLC, Chicago, IL
- Where to order
- klow.bio
Semax research resources
Every Semax resource on semax.bio, organized from chemistry to documentation.
Semax specifications
Formula, molecular weight, sequence, modifications and release specification.
QualityQuality and supply chain
Sourcing, specifications, batch documentation and release.
TestingAnalytical testing
How every lot is tested, reviewed and released.
TestingHPLC analysis of Semax
Retention time, peaks, area normalization and results by lot.
DocumentationCertificates of analysis
Every lot's full results, plus the complete testing records.
DocumentationHow to read a Semax COA
What each section means and what a COA does and doesn't establish.
DocumentationVerify a lot
Look up any Semax lot by the number on the vial.
AnalysisPurity, content and net content
Three different numbers, kept apart.
HandlingStorage and stability
Degradation pathways and lyophilized peptide handling.
ReferenceGlossary
Definitions for every term on a Semax certificate.
Research materialSemax research material
Sizes, current lots and availability. Purchasing is handled through Klow.bio.
Research references
Published sources
- PubChem: Semax. National Library of Medicine, NIH. pubchem.ncbi.nlm.nih.gov/compound/9811102
- NCBI Gene: POMC (proopiomelanocortin, the ACTH precursor). National Center for Biotechnology Information, NIH. www.ncbi.nlm.nih.gov/gene/5443
- Wilm M. Principles of electrospray ionization. Mol Cell Proteomics. 2011. PMC3134074. pmc.ncbi.nlm.nih.gov/articles/PMC3134074
- U.S. FDA. Q2(R2) Validation of Analytical Procedures. 2024. fda.gov
- U.S. FDA. Pyrogen and Endotoxins Testing: Questions and Answers. Revised 2026. fda.gov
Semax Labs analytical documentation
- Lot KB29412: 10 mg, 99.84% purity, reported Jun 7, 2026
- Semax testing records (all tests, all lots; CSV available)
Editorial scope
Semax Labs research content covers molecular characteristics, peptide structure, analytical chemistry, purity and identity testing, certificates of analysis, lot documentation and laboratory storage and handling.
It does not cover dosing, administration instructions, protocols, personal use or medical advice.
Latest updates
Buy Semax
10 mg vials. Current lot KB29412 tested at 99.84% purity with identity confirmed by LC-MS. Current purchasing is available through Klow.bio.